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Met ID


Met ID

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The MetID team can study the metabolic pathway of your compound (cold or 14C-labeled) using in vitro (cellular and microsomal) and in vivo systems followed by high resolution MS and NMR to determine the number and structure of the major metabolites. For late nonclinical or clinical stage Met ID, the Plainsboro, NJ site run by XBL can help with IND or NDA-enabling studies.

Metabolite Identification and Profiling In Vitro

  • Hepatocytes, S9 fractions, microsomes

Metabolite Identification and Profiling In Vivo

  • Plasma, urine, bile, feces

Reactive Metabolite and Intermediate Trapping

  • GSH, CN

Instruments

  • API 4000 Q-TRAP LC-MS/MS systems coupled with HPLC and UPLC
  • Waters Xevo G2 Q-TOF UPLC-MS/MS system
  • PE Model 307 sample oxidizer
  • PE Tri-Carb 2900 TR liquid scintillation analyzer
  • PE Radiomatic 610 TR flow scintillation analyzer
  • PE Microbeta Trilux 1450 reader

GSH Trapping of Reactive Metabolites: APAP

DMPK 2