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Pharmacodynamic Evaluation in Non Human Primates


Pharmacodynamic Evaluation in Non Human Primates

Pharmacodynamic Evaluation in Non Human Primates

  • Pharmacodynamic evaluation in metabolic disease models (read more)
Obesity Diabetes Lipid metabolism disorders
  • Daily food consumption
  • Animal body weight
  • Body mass index(BMI)
  • Adipose tissue biopsy
  • Dual energy X ray detect body fat composition
  • Clinical pathology
  • Histopathology

Type 1 Diabetes Mellitus (TIDM):streptozocin (STZ) induction

Insulin resistance (Pre T2DM) and T2DM models

  • HbA1C, Fructosamine
  • Intravenous glucose tolerance test (IVGTT)
  • Intravenous insulin tolerance test (IVITT)
  • Oral glucose tolerance test(OGTT)
  • Arginine stimulating – intravenous glucose tolerance test (ARG-IVGTT)
  • Glucose clamp (Hyperinsulinemic- euglycemic clamp technique, hyperglycemic clamp)
  • Glomerular filtration rate in kidney disease of diabetes
  • Urinary glucose
  • Dyslipidemia
  • Non-alcoholic fatty liver disease / nonalcoholic steatohepatitis (NAFLD/NASH model is on establishing)
    Liver biopsy
    hepatic fibrosis indexes