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In Vivo PK


In Vivo PK

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WuXi DMPK operates two animal facilities: a 14,000 ft2 AAALAC-accredited vivarium in Shanghai which handles all small rodent studies, and a 10,000 ft2 AAALAC-accredited vivarium in nearby Suzhou for large animal PK/TK studies. Both facilities keep an adequate animal supply to eliminate lead time resulting in a 5-7 day turnaround time from compound receipt to report issuance. Additionally the DMPK team can do full mass balance and tissue distribution studies using cold material or 14C-labeled material. For our client’s convenience, WuXi's Chemistry Division can synthesize the 14C-labeled material to expedite the process and decrease overall costs.

Multiple Animal Species

  • Mouse, rat, hamster, guinea pig, rabbit, mini pig, beagle, cynomolgus monkey

All Administration Routes

  • PO, IV, SC, SL, IP, IM, topical administration

All Biological Matrices

  • Whole blood, plasma, urine, feces, bile, CSF, lymph fluid, tissue homogenate

Myriad Surgery Models and Techniques

  • Cisterna magna cannulation
  • Bile duct cannulation
  • Portal vein cannulation
  • Thoracic duct cannulation
  • Intraduodenal administration

Mass Balance

  • Biliary versus urinary excretion rates
  • Tissue distribution

Experienced Veterinarians and Strictly Executed Animal Welfare Policies

Data Correlation – Dry Blood Spot vs Routine Sample Extraction

DMPK 3