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In vitro/ in vivo ADME


In vitro/ in vivo ADME

DMPK
  • Permeability
  • Plasma protein binding
  • RBC partitioning
  • Transporter profiling
  • DDI  (CYP inhibition / induction)
  • Phenotyping 
  • PK / bioavailability
  • MetID  (in vitro / in vivo)
  • Radiolabeled and unlabeled  mass   balance  and tissue   distribution
Bioanalysis
  • Biomarker analysis (soluble, cell, tissue, genetic)
  • Small/Large molecule bioanalysis (GLP-like / GLP)

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